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[44] Koyyada A, Orsu P

193 Furthermore, combining DDR inhibitors with ICB enhances antitumor immunity by promoting neoantigen exposure, micronuclei formation, and activation of the cGASSTING pathway

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Participants receiving 2.4 mg of Sema weekly, alongside lifestyle modifications, experienced an average 14.9% reduction in body weight over 68 weekssubstantially more than the placebo group

At lower starting doses the effect may not last a full 7 days but as your dose increases through titration, appetite control becomes more consistent across the week