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These data are limited and uncontrolled, so they should guide, not guarantee, expectations
But I'll say that we still would like to see controlled trials to determine how much of the effect is directly attributable to the medication versus just the weight reduction itself
For researchers who need or want the greatest possible weight reduction, the approximately 6 percentage point advantage of retatrutide represents a meaningful difference
Impotence (erectile dysfunction) has been reported in with spironolactone therapy
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