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As one of the most abundant intracellular antioxidants found in human cells, glutathione is essential for maintaining cellular health and physiological homeostasis
The role of CRF as an anorexigenic hormone may involve the NPY, melanocortin and CART systems, acting in a downstream fashion
Such enzymatic inhibition thus blocks the synthesis of glutathione
All spectral data have been smoothed, baseline corrected and CO 2 corrected
Yet, under regulation of the ISR pathway an ATF4-mediated upregulation of NRF2 via CHAC1 activity was shown as well (Kre et al., 2023), revealing a context-dependent interplay between CHAC1 and NRF2 that merits further study
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