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2016;311(3):E620-E627
Manufactured using validated peptide synthesis methodologies
What they found: Cagrilintide 4.5 mg: 10.8 % weight reduction vs 3.0 % placebo (p 40 % of patients achieved 25 % weight reduction , historically unprecedented Safety profile in line with Phase 2 data Why it matters: REDEFINE 1 confirmed CagriSema as the largest body-weight signal reported in the published incretin literature to date
10.1038/nrc3818 Nat
The peptides proposed mechanism involves activation of the VEGFR2 pathway (promoting angiogenesis), nitric oxide synthesis via the Akt-eNOS axis, and modulation of the dopaminergic system
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