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Perhaps its most famous role, GLP-1 crosses the blood-brain barrier to act directly on appetite centres in the brain, enhancing feelings of fullness and reducing hunger signals
GLP-1 receptor analogs, such as exenatide, have a beneficial effect on bone health in women with type 2 diabetes who have gone through menopause (66)
BALANCE Model (2027+): A longer-term demonstration program that aims to integrate GLP-1 coverage into Medicare Part D permanently, with a requirement that beneficiaries participate in lifestyle modification programs
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Preclinical studies with GLP-1 agonists have raised questions about thyroid C-cell tumours in rodents, though this has not been confirmed in humans
