Notably, similar to the native GLP-1, binding of SR18 to GLP-1R also induces structural changes in the conserved motifs (Figure 17) in comparison to the inactive (PDB: 6LN2) GLP-1R (Wu et al., 2020), which is crucial for intracellular signaling of GLP-1R
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10.1002/cbin.10466 Summary Keywords fetal growth, skeletal muscle, myoblast, IGF-1 signaling, IGF binding protein Citation Stremming J, White A, Donthi A, Batt DG, Hetrick B, Chang EI, Wesolowski SR, Seefeldt MB, McCurdy CE, Rozance PJ and Brown LD (2022) Sheep recombinant IGF-1 promotes organ-specific growth in fetal sheep
Identical proportions of participants in both groups (3.4%) reported serious AEs (Table 2)
It also causes a slowing down in how fast the stomach empties