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While the semaglutide CVOTs did not show an increased incidence of hospitalization for HF compared to placebo (101), in earlier smaller studies with liraglutide in patients with HF with reduced left ventricular ejection fraction, the GLP-1RA was associated with increased incidence of serious cardiac events (rhythm disorders, worsening of HF) (102, 103)
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Moreover, SDV led to a reduction in the expression of c-Fos + cells within the AP, NTS, and DMV regions in ABX mice after OFT (Supplementary Fig
