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Therefore, an increased supply of Met may increase antioxidant production, potentially aiding in the relief of oxidative stress and inflammation triggered by the production of reactive oxygen metabolites ( Conversely, Hcy has the capacity for remethylation to regenerate methionine, which relies on the folate cycle and vitamin B 12 ( Figure 1 ) ( 2 -THF), which is subsequently reduced to 5-methyltetrahydrofolate (5-CH 3 -THF) (Preynat et al., 2009)

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Brightens and evens out skin tone reduces dark spots and pigmentation

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Yet, the expression of this transporter in different parts of the gut (Figure 2B) does not exclude its possible participation in the guts absorption of ThDP from the diet, especially given the presence of other folate transporters on the brush border membrane of enterocytes, i.e., those encoded by SLC46A1, FOLR1, and FOLR2 (119)