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In February 2026, Commissioner Marty Makary announced the agency's intent to crack down on non-FDA-approved GLP-1 compounding

The three most effective (semaglutide, tirzepatide, retatrutide) are GLP-1 agonists: they mimic a natural gut hormone that tells your brain you are full

This synergistic approach is a common theme across our entire collection of research peptides, where different compounds can be used to study different pathways

Using both pharmacological and genetic approaches, we demonstrated that liraglutide retained antidepressant efficacy in GLP-1R antagonist-Exn9-treated mice or in Glp1r / mice, whereas gut microbiota depletion abolished its effects

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