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EMA EPAR database, accessed April 2025)

They slow the disease rather than restoring lost function, and the evidence is specific to people who already have early Alzheimers with confirmed amyloid, though secondary prevention trials are now testing whether clearing amyloid in cognitively normal but amyloid-positive people can delay the disease

538 UPS-targeted therapies in autoimmune diseases MDM2 inhibition MDM2, an E3 ligase best known for regulating p53 stability, also contributes to immune dysregulation

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