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it is an unresolved question
The mechanism is documented across multiple systematic reviews
Such depletion can be due to reduction of GSH due to excessive NAPQI exposure and/or to GSH depletion associated with elevated dopamine secondary to dopamine -hydroxylase inhibition by phenolic Clostridia metabolites
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Individuals who live in malaria endemic areas are also screened for G6PD status before administration of 8-aminoquinolone compounds
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