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C57BL/6J mice Inbred mouse strain that is the preferred mouse model used in metabolic research to study the effects of a Western diet and for genetic manipulations

That is a personal and clinical judgment, not a productivity contest

Joint pain and overweight all go hand in hand

Importantly, the Sema + -MSTN/-ActA group which had similar body weight reduction but increased lean mass compared to Sema alone also had markedly greater losses in fat mass, almost twice that seen with Sema alone (Fig