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doi: 10.1054/JCPT.2000.18011

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Pflanzenstoffe: Bestimmte Obst- und Gemsesorten enthalten Stoffe in hoher Konzentration, die die Glutathion-Enzyme aktivieren

That flat selectivity profile is precisely what keeps MT2 useful in vitro: it serves as the positive-control full agonist against which subtype-selective ligands are benchmarked, and it is the parent scaffold for a large derivative family generated by single substitutions at positions 6, 7 and 9, including the MC3R/MC4R antagonist SHU-9119