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The table juxtaposes two non-comparable measures: US-site pooled enrollment in trials supporting approvals from 2015 to 2019, and the share of 2023-approval trials meeting a representativeness threshold in a later dataset that includes international recruitment

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The Croatian Phase I and II clinical trials for inflammatory bowel disease conducted in the 1990s by pharmaceutical company Pliva claimed safety with no significant toxicity, though complete peer-reviewed data never appeared in scientific literature beyond conference abstracts

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