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Description

This entry summarizes the mechanistic literature on BPC-157 with a specific focus on what is and is not known about the intranasal route of administration a route of interest to researchers because it bypasses first-pass hepatic metabolism and may provide partial access to the central nervous system via the olfactory and trigeminal pathways described by Illum [6]

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[16] [17] Whereas the latter directly act on the dopamine transporter (DAT) to inhibit the reuptake and/or induce the release of dopamine, bromantane instead acts via indirect genomic mechanisms to produce a rapid, pronounced, and long-lasting upregulation in a variety of brain regions of the expression of tyrosine hydroxylase (TH) and aromatic L-amino acid decarboxylase (AAAD) (also known as DOPA decarboxylase), key enzymes in the dopamine biosynthesis pathway

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b) Another study published in the European Journal of Pharmacology showed that BPC-157 counteracted the hypertensive effects induced by certain substances, further highlighting its potential as a blood pressure regulator

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