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These SAR studies established the conformational basis for melanocortin receptor subtype selectivity and the design principle that cyclisation of the -MSH pharmacophore core produces central melanocortin receptor-preferential biology
Objective evaluations were scored according to spot ultraviolet (UV), spot polarization, skin tone, and efficacy on the medial side of the face photographed using a Janus Facial Analysis System (PIE Co., Ltd, Suwon-si, Gyeonggi-do, Korea), which uses a pigment technology system that assesses the pigment distribution objectively according to three light exposure typesnamely, normal, polarizing, and UV light
Step 3: Pair it with other supports
