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Although AFLD is usually considered a benign and static lesion, it can develop irreversible liver damage in a short period of time, MASLD is caused by high-fat diet (HFD), high-fructose diet, methionine- and choline-deficient diet (MCD), gene mutations, and heavy-metal poisoning

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Furthermore, ZO-1-deficient colonic epithelia failed to upregulate proliferation in response to damage in vivo or Wingless-related integration site (Wnt) signalling in vitro

Key takeaways While no vitamins need to be avoided completely, some supplements, like iron, vitamin C, and magnesium, could do more harm than good when taken in high doses

We start with the dominant symptom, monitor response, and add therapies in a staged fashion, always weighing metabolic and oncologic risks