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These inter-tissue differences were likely due to differences in the proliferation rate and different life spans of the various cell types, and also in oxidative stress levels in these tissues
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& Sternberg, P
In amyotrophic lateral sclerosis (ALS), mitochondrial impairmentsincluding reduced ATP synthesis, altered axonal distribution, morphological changes, elevated ROS production, and respiratory chain defectsare associated with rapid disease progression (35)
Glutathione also plays an important role in the detoxification process via its use as a cofactor
