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Behavioral modification represents the starting point for obesity prevention and management
Patients and providers should prioritize safety and rely on evidence-based treatments
Moreover, patients with T2DM have impaired incretin action, which highlights GLP-1 as a useful pharmacotherapy for restoring glucose control (reviewed in Madsbad, GLP-1R agonists The GLP-1R agonists mediate their action by acting directly on the GLP-1R
Metformin has also been shown to improve insulin secretion from rat islets chronically exposed to high levels of NEFA or glucose [21], suggesting a direct effect on pancreatic beta cells independent of its glucose-lowering action
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