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Without human trials, clinicians cannot reliably determine appropriate dosing, long-term risks or whether benefits outweigh risks
NHS inform in Scotland describes the same broad approach
Quality and regulation : Most oral B12 supplements are regulated as food supplements under food law, while injectable B12 and some oral preparations are licensed medicines regulated by the MHRA
Diet, stress, illness, lack of exercise, and even aging can deplete your natural supply
Trial populations and endpoints differ across the published studies, and results vary considerably from one person to the next
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