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Some studies emphasize an important challenge in using BAT activation as therapy, since patients need to have sufficient BAT mass and activity to benefit

Conclusions These findings suggest a potentially elevated risk of vision impairment with semaglutide use compared to other diabetes and weight loss medications, warranting further investigation and vigilant post-marketing surveillance

But it has limitations: its observational design cannot prove causation

The mean systolic blood pressure was reduced by 3.4 mmHg at a dose of 0.5 mg and 5.4 mmHg at 1 mg in SUSTAIN-6

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