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This macrophage reprogramming is associated with SFN-mediated inhibition of the transcription factor c-Myc, which normally drives M2 polarization, and concurrent activation of the Nrf2 pathway that favors M1-associated gene expression profiles (78)

Presented for research literature review only Spielmans GI (2021)

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Physical activity contributes to weight loss, may decrease abdominal fat, and may help with maintenance of weight loss Berberine, Inositol, and L-Carnitine rank highest in the literature as the most effective therapeutic dietary supplements for PCOS References References An Y, Sun Z, Zhang Y, Liu B, Guan Y, Lu M