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34x/week is optimal Use progressive overload: gradually increase weight, reps, or sets over time Do not replace resistance training with cardio add cardio on top of resistance training, not instead of it Consider creatine monohydrate supplementation (35g/day) for training support Supplementation Consider daily free-form EAA supplementation, additional servings can be taken between meals when protein targets are difficult to hit from food or before activity Consider omega-3 supplementation if fatty fish intake is low Monitor and address vitamin D, B12, and iron status through regular bloodwork Monitoring Track body composition (not just scale weight) through DEXA, BIA, or circumference measurements Monitor gym performance a sustained decline in strength is a meaningful warning sign Regular bloodwork for micronutrient status every 36 months while on GLP-1 therapy Summary GLP-1 receptor agonists including semaglutide and tirzepatide are highly effective for weight loss, but they create a nutritional environment where lean muscle mass is at significant risk
Dihexa and Cognition Dihexas effects on cognition have been a subject of research interest
People with kidney disease Semaglutide itself does not require dose adjustment for kidney impairment
Untreated symptoms such as ongoing bloating or irregularity can considerably diminish your quality of life
Drug working concentrations and stock preparation were as follows: GLP-1MK-801 and MK-801 (both 50 M, dissolved in aCSF or magnesium-free aCSF), NMDA (100 M, dissolved in magnesium free aCSF), CNQX (10 M, dissolved in DMSO, Alomone Labs), picrotoxin (100 M, dissolved in DMSO)
