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Research on IGF-1 receptor dynamics shows that receptor density decreases by approximately 40-60% after 6 weeks of continuous supraphysiological IGF-1 exposure (Yakar et al., 2002)

This pharmacokinetic profile has made it a subject of investigation in neuroendocrinology, sleep research, and stress physiology at the laboratory level

doi: 10.3389/fendo.2023.1133000 Received 28 December 2022 Accepted 13 March 2023 Published 24 March 2023 Volume 14 - 2023 Edited by Silvia Martina Ferrari, University of Pisa, Italy Reviewed by Sabrina Rosaria Paparo, University of Pisa, Italy

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While this M1/M2 classification oversimplifies microglial diversity, it remains useful for distinguishing functional profiles [124, 125]