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Transdermal routes often struggle with penetration in a predictable way

If your body has a vitamin B12 deficiency, this can affect the replication of DNA, which may increase the risk of cancer, heart attack, or stroke

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However, a very small percentage of B12 from a supplemental dose is absorbed by passive diffusion, rather than by intrinsic factor, such that vegans can make up for taking B12 only once per day, or even only once per week, by taking larger doses than normally provided by food