Important Note: Seek urgent medical care for trouble breathing, swelling of the face or throat, widespread hives, dizziness, or symptoms that suggest a serious allergic reaction
Together, these observations lead to the conclusion that the formation of NAPQI by Cyp2E1 and the formation of protein adducts, especially on mitochondria, are initiating events leading to mitochondrial dysfunction and mitochondrial oxidant stress (Fig
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They are usually dimers, but occasionally tetramers
Clinically, the results of the injectable and oral formulations are comparable, with the main difference being how the medication enters the bloodstream