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Though G6PD is found in the cytoplasm of all mammals cells, its deficiency is more evident in the red blood cells probably because these cells live without nucleus for a long time and because they contain proteases that degrade the mutant enzyme in major degree than other proteases in other tissues 1
Targeting glutaminolysis has antileukemic activity in acute myeloid leukemia and synergizes with bcl-2 inhibition
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