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I was thinking along the lines of just taking one tablet if I developed a headache to see if it made any difference
Additionally, rectal administration can result in higher bioavailability and faster onset of action compared to some other routes, as the medication bypasses the first-pass metabolism in the liver
(PubMed) Raza S, Rajak S, Upadhyay A, Tewari A, Anthony Sinha R
Although its not fully understood, several factors appear to be at play: 1
The two most common forms are cyanocobalamin and methylcobalamin
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![Mechanism of action of GLP-1 [25]](https://www.researchgate.net/publication/256289222/figure/fig1/AS:614177232142337@1523442671231/Mechanism-of-action-of-GLP-1-25.png)
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