Since the inability to proliferate and the emergence of SASP are key events defining cellular senescence in nucleated cells, it is a much more rigorous task to distinguish senescence and eryptosis in RBCs than senescence and apoptosis in nucleus-containing cells
Statements Author contributions MG and RP have contributed to the conception or design of the work, participated in the drafting of the manuscript and revising it critically for important intellectual content, approved the manuscript for publication and agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved
Across multiple STEP trials, the enrollment criteria required a BMI of 30 or higher, or 27 or higher with at least one weight-related comorbidity (excluding type 2 diabetes, which was studied separately)
Long-Term Success: By combining medication with lifestyle changes, our medical weight loss program aims to provide the tools and strategies needed for long-term success, promoting lasting health and wellness
PMID: 41999297 Guldhammer A et al