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Some reports suggest potential improvements in inflammatory markers or disease activity, while others note no significant effect or even symptom exacerbation related to gastrointestinal adverse effects

An excess production of melanin can occur as a result of sun exposure or hormonal variability and may result in pigmentation, tanning and uneven tone

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This food-first approach may also encourage the microbial activity and gut-brain signaling that influence appetite and digestion

Peer review Peer review information Nature Aging thanks Ziyad Al-Aly, Yadong Huang and Olivier Rascol for their contribution to the peer review of this work