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CVB-associated T1D may also be caused by the viral-associated effects on central tolerance

RAGE engages in interactions with a variety of DAMPs, such as HMGB1, S100 proteins, histones, amyloid , and extracellular DNA, thus mediating cellular responses to these ligands [222]

Several experiments suggest that simultaneously activating the GHS-R1a and GHRH receptors may produce combined and synergistic actions

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