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A key challenge in studying native GLP-1 is its extremely short in vivo half-life of approximately 12 minutes, owing to rapid inactivation by dipeptidyl peptidase-4 (DPP-4), which cleaves the N-terminal His-Ala dipeptide from GLP-1 to produce the inactive metabolite GLP-1(936)amide

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The dose increases gradually and should be tapered when stopping to reduce seizure risk

The abdominal wall itself is usually intact

However, some individuals may experience mild stomach discomfort or nausea after taking Tylenol on an empty stomach, although this is relatively rare