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Mechanistically, resistance to ICB can be broadly categorized into tumor-intrinsic determinants and tumor-extrinsic constraints, which together shape immune responsiveness
Background care (concomitant use of statins, angiotensin converting enzyme inhibitors /angiotensin receptor blockers, beta-blockers and dual antiplatelet therapy) may also play a role in this discrepancy
L.DickerD.MingroneG.PedersenS
These are found in about 0.005% of the population
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