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About one-third of participants lost 20 percent or more. LaValle explains that the 16.6 percent average weight loss seen with the Wegovy pill reflects several factors, including the higher 25 mg dose, the 64-week length of the trial, the diet and activity coaching participants received and the strong biological effects of semaglutide as a GLP-1

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Future Research Directions Future research should focus on identifying which patients have clinically meaningful retained gastric contents and which mitigation strategies reduce risk without causing unnecessary cancellations or metabolic harm

Apply moisturizer twice daily, especially around the mouth area

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