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While Ser2 of oxyntomodulin and Ala8 of GLP-1 both interacted with TM7 residues, these interactions were stronger with oxyntomodulin due to a persistent hydrogen bond between Ser2 and E387 7.42 and transient hydrogen bonds and van der Waals contacts with K383 7.38 , D372 ECL3 and L384 7.39 (Supplementary Table 3)
Tan Q, Akindehin SE, Orsso CE, et al
Lam Q, Li Y, Luthra R, Juroske D, Lennon P, Hu P, Constance A
These findings have made retatrutide one of the most closely watched investigational therapies in obesity medicine
"This level of drop off is concerning because these medications aren't meant to be a temporary quick fix," study author and epidemiologist professor Reimar W
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