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Medical concepts are systematically categorized using the Medical Dictionary for Regulatory Activities (MedDRA) terminology, with Preferred Terms (PTs) representing granular AE descriptions, hierarchically grouped into High-Level Terms (HLTs), High-Level Group Terms (HLGTs), and System Organ Classes (SOCs) 18,19

Collectively, these data imply that the impact of NSW on telomere length may depend on the duration and intensity of exposure, with short to moderate durations having a limited effect, but long-term or consecutive NS contributing to telomere shortening and potentially premature cellular aging

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Female patients exhibited dramatically higher total reactive oxygen species (ROS) and mitochondrial calcium levels, correlating with the hyperproliferation of memory T cells

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