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Depending on the nature of the substance and especially the attacked group, several reactions can take place: glucuronidation conjugation of a COOH or OH group with glucuronic acid, acetylation isoniazid, sulfonamides, aniline derivatives, polymorphism in acetylase makes treatment of tuberculosis with isoniazid problematic conjugation with glycine acetylsalicylic acid, nicotinic acid, conjugation with glutathioneem epoxides, nitro compounds, ethacrynic acid, formation of ethereal sulfates minor pathway of phenolic compounds
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J Pharm Pharmacol 2015;67(7):879-899
Research Applications NNMT Enzyme Research 5-Amino-1MQ is studied as a selective NNMT inhibitor
Genetic testing not standard but may explain differential peptide responses
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