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Liu Z, Yang Z, Wu J, Zhang W, Sun Y, Zhang C, et al
Although IFN- suppresses tumor-derived chemokines to inhibit the tumor trafficking of CXCR2 + CD68 + macrophages (associated with M2 polarization) by blocking the CXCL8-CXCR2 axis, thereby counteracting immunosuppression and overcoming therapeutic resistance, dysregulated IFN signaling can promote M2-skewed macrophage polarization, which compromises the efficacy of anti-PD-1/PD-L1 therapies [299]
The Src-Caveolin-1-eNOS pathway produces nitric oxide for vasodilation and improved blood flow
However, these results are from mice with defined genetic backgrounds, and human kidneys differ in important ways from murine kidneys
Distinct myocardial targets for diabetes therapy in heart failure with preserved or reduced ejection fraction
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