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The complexity associated with obesity necessitates a multifaceted approach, pulling in elements of medicine, psychology, and social support networks

Many studies do not fully control for dietary intake, physical activity, or concurrent lifestyle changes all of which independently affect weight and cardiometabolic risk

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mRNA levels have served as a proxy for protein levels, although the correlation between mRNA and protein abundance has generally not been shown to be very strong, e.g., due to additional transcriptional and translational regulation 25,26,27

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