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IGF-1 induces rat glomerular mesangial cells to accumulate triglyceride [PMID: 16077083] Laboratory literature summary: IGF-1 induces rat glomerular mesangial cells to accumulate triglyceride
Desiree Granados Quick Summary: GLP-1 medications may reduce obstructive sleep apnea severity indirectly by promoting significant weight loss and improving metabolic health, which can decrease upper airway obstruction and inflammation
Sampedros team (Sampedro et al., 2019) discovered in mice that treatment with GLP-1RAs resulted in a significant decrease in VEGF levels in the retina, kidneys, and systemic circulation
But those taking a GLP-1 for weight loss may think about reducing their dose or even stopping completely once they reach their goal weight
Yes, SGLT2 inhibitors should be temporarily discontinued 3 days before major surgical procedures requiring fasting and during acute illness, particularly if experiencing reduced food intake, dehydration, or persistent vomiting
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