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In aged C57BL/6J dermal fibroblasts, GHK-Cu (1 g/mL) activates Nrf2 nuclear fraction from 22% to 48% of young control (ML385 reduces to 28%, confirming Nrf2 dependence), HO-1 +1.82.2, NQO1 +1.61.8, GPx +1.31.5

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the 2023 Duke Science Advances work showing polystyrene nanoplastics accelerate Parkinsons alpha-synuclein aggregation

The concentrations of carnosine in the olfactory bulb of the brain and the cardiac muscle are comparable to those in skeletal muscle, but those in other tissues (e.g., ~ 0.1 mM in kidneys and adipose tissue) are only 0.1% to 10% of those in skeletal muscle