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A 2018 European Thyroid Association survey on the use of selenium supplementation in Graves hyperthyroidism and Graves orbitopathy
The side-chain guanidyl group of Arg454 interacts with the carboxylate moiety of glycine to orient the substrate for attack on the acyl-phosphate intermediate (Herrera et al., Unlike other organisms, some plants synthesize glutathione analogs in which -alanine, serine, or glutamate replaces glycine in the tripeptide (Figure 4A)
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Additionally, T2DM poses a significant risk for AP, particularly among younger diabetic patients (Wolfe et al., 2020)
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