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Annals of the New York Academy of Sciences, 368-386, 1986

At higher doses, more TMA is produced than the body's enzymes can fully oxidize, and the excess is cleared through breath, sweat, and urine producing the odor some users report

When to seek medical advice : Contact your GP or diabetes specialist promptly if you experience: Severe, persistent vomiting or diarrhoea leading to dehydration Severe abdominal pain, particularly if radiating to the back (potential pancreatitis) Signs of hypoglycaemia (if taking insulin or sulphonylureas concurrently) Symptoms of gallbladder problems (pain in the upper right abdomen, fever, yellowing of skin) Any changes in vision (rapid improvement in blood glucose can sometimes worsen diabetic retinopathy) [20] Unexplained persistent nausea beyond the first few weeks If you are planning pregnancy, discuss this with your healthcare provider as GLP-1 RAs are not recommended during pregnancy or breastfeeding

Multiple studies demonstrate that when people stop using these medications, they regain most of the weight lost within a few months unless they have made diet and lifestyle changes