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Microbial metabolites primarily short-chain fatty acids, bile acid secondary metabolites, and tryptophan-derived indoles stimulate GLP-1 secretion from L-cells through FFAR2/FFAR3 signaling and related mechanisms (Kouraki et al., 2026)
October 1, 2025: Most Ozempic Users Stop Taking It Within First Year of Starting, Study Finds A new study has found that most people who take Ozempic discontinue treatment within 1 year
What it doesnt capture: the metabolic changes underneath improved blood pressure, better cholesterol markers, more stable blood sugar which are arguably the more clinically meaningful part of the trial data
One reason: Changes in stomach acid can be part of aging, and you need hydrochloric acid in your stomach to absorb B12
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