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Before a drug can legally be marketed for a new intended use or indication for use (e.g., new patient population), the safety and efficacy of the new intended use or indication for use must be demonstrated through well-controlled clinical trials

Infect Immun (2004) 72(3):13916

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Regarding the crosstalk between iron and inflammation, previous research has shown that PICs led to increased expression of DMT1 and iron accumulation in neurons and glia (61), which potentially triggers O&NS and PICs secretion by these cells, further contributing to CNS damage

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