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Radiological Studies with Contrast: Administration of intravascular iodinated contrast agents in metformin-treated patients has led to an acute decrease in renal function and the occurrence of lactic acidosis

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This is based on animal studies that showed using the medication in pregnancy was associated with pregnancy loss as well as an increased rate of birth defects

Pregnancy and Breastfeeding GLP-1 medications are not recommended for pregnant women or those who are breastfeeding