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The next frontier is multi-agonist incretin therapy: single molecules activating two or more hormone receptors simultaneously, offering superior weight loss and metabolic benefits compared to GLP-1 alone
10.2337/db10-0474 97
Under these circumstances, the evidence strongly supports waiting
High cortisol is notoriously bad for insulin sensitivity
The data shows Tirzepatide skews the ratio toward fat loss more than lean mass loss compared to diet alone, and you can protect your muscle further by eating enough protein and staying active while youre on it
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