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Practical strategies to manage initial heart rate elevation include staying well-hydrated (810 glasses of water daily), avoiding sudden position changes to prevent orthostatic hypotension, and limiting caffeine and stimulants while your body adapts

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In addition, loss of lean muscle mass is a serious concern, as some users end up with poorer body composition following treatment

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Some research has found that these meds may be associated with gastroparesis (stomach paralysis) and bowel obstruction