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REDEFINE 1 (obesity, no diabetes) A phase 3a, 68-week, multicentre, double-blind, placebo- and active-controlled trial (NCT05567796 [10] ) enrolling 3,417 adults without diabetes with BMI 30, or 27 with at least one obesity-related complication
Women with lower body fat may experience vaginal dryness, reduced sensitivity, or lower overall desire
Over one year of treatment, a GEHA member might spend $3,600$6,000 on insurance-covered or denied Wegovy, while PlexusDx patients invest $2,268/year ($189/mo) in compounded semaglutide
Each has been studied separately in small clinical trials with modest results
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