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Animal safety studies are remarkably reassuring

7 Of the four peptides in these blends, GHK-Cu has the most substantial cosmetic and dermatological evidence base, though it is important to be precise about what that evidence is

These effects are mediated by downregulation of VE-cadherin, occludin, and claudin-5 and increased levels of oxidative stress in endothelial cell monolayers and co-cultured with pericytes

5,11 Laboratory studies have examined GHK's effects on lipid peroxidation markers and reactive oxygen species (ROS) levels across various cultured cell types